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Molecular mechanisms of chondrosarcoma metastasis

  • Chih-Hsin Tang

      Affiliations

    • Department of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan
    • Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan
    • Corresponding Author InformationDepartment of Pharmacology, School of Medicine, China Medical University, No. 91, Hsueh-Shih Road, Taichung, Taiwan.

Received 15 November 2011; received in revised form 30 December 2011; accepted 12 January 2012. published online 16 February 2012.
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Abstract 

Chondrosarcoma is highly malignant, with a strong capacity for local invasion as well as distant metastasis. Surgical resection remains the primary mode of therapy. This cancer shows a predilection for metastasis to the lungs. This article will highlight numerous molecular mechanisms mediating cell motility, as described in such cases. Numerous experiments have demonstrated that upregulation of integrin and matrix metalloproteinases (MMPs) and intercellular adhesion molecule-1 (ICAM-1) expression lead to increased tumor cell migration and invasion. Data from these experiments suggest that targeting these pathways and molecules may enhance control of chondrosarcoma and decrease metastasis ratio.

Keywords: chondrosarcoma, ICAM-1, integrin, migration, MMP

 

PII: S2211-8020(12)00004-6

doi:10.1016/j.biomed.2012.01.001

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